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Cefixime

Cefixime
Cefixime is prescribed for infectious and inflammatory diseases caused by microorganisms sensitive to the drug: pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, otitis media, uncomplicated urinary tract infections, uncomplicated gonorrhea.

Brand: Cefixime

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: September 2023
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Cefixime 200 mg
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Cefixime 100 mg
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Product description

Pharmacy of Cefixime

Buy Cefixime in Canada

Cephalosporin antibiotic of the third generation for parenteral use. Acts bactericidal (violates the synthesis of the cell wall of microorganisms). Has a wide spectrum of action, which includes various aerobic and anaerobic gram-positive and gram-negative microorganisms, incl. Pseudomonas aeruginosa. Resistant to beta-lactamases of both gram-positive and gram-negative microorganisms. Highly active against Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis (including strains producing beta-lactamases), Escherichia coli, Proteus miseella vulrhalis oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter spp. (including Citrobacter diversus), Serratia marcescens. Pseudomonas spp., Acinetobacter spp., Some strains of Streptococcus, Enterococcus spp. (methicillin-resistant strains), Listeria monocytogenes, Bacteroides fragilis, most of Staphylococcus, Enterobacter and Clostridium strains are resistant to cefixime.

Pharmacokinetics

When taken orally, bioavailability is 40-50%. Food increases the time of maximum absorption by 0.8 hours. TCmax - 2-6 hours for tablets and suspension 400 mg / 5 ml and 2-5 hours for suspension 200 mg / 5 ml. Cmax after oral administration of 100, 200 and 400 mg - 1-1.3, 2-3 and 3.5-4.4 μg / ml, respectively. After taking the suspension, Cmax is 25-50% higher (due to the difference in bioavailability, it is not recommended to replace the suspension with tablets in the treatment of otitis media). Cmax in urine after administration at doses of 100, 200 and 400 mg - 73, 107 and 164 μg / ml, respectively. High concentrations of the drug persist for a long time in blood serum, bile, urine. T1 / 2 - 3-4 hours, with renal failure - 6.4-11.5 hours. The volume of distribution is 0.11 l / kg. The connection with plasma proteins is 65-70%. It is excreted by the kidneys unchanged - 50%, with bile - 10%.

Cefixime indications for use

Tonsilitis treatment with Cefixime

Bacterial infections of the upper and lower respiratory tract (pharyngitis, tonsillitis, sinusitis, acute bronchitis and exacerbation of chronic bronchitis), urinary tract infections (uncomplicated);

  • otitis media,
  • uncomplicated gonorrhea of ​​the urethra and cervix.

Cefixime dosing

Inside. In an average daily dose for adults and children over 12 years old with a body weight of more than 50 kg - 400 mg 1 time per day or 200 mg 2 times a day.

The daily dose for children weighing less than 50 kg is 3-9 mg / kg; if necessary, the dose can be increased to 12 mg / kg. Multiplicity of appointment for adults - 2 times; children - 2-3 times a day. The average duration of treatment is 7-10 days.

Children under the age of 12 are prescribed in the form of a suspension, at a dose of 8 mg / kg 1 time per day or 4 mg / kg every 12 hours.

For children aged 5-11 years, the daily dose of the suspension is 6-10 ml, at the age 2-4 years old - 5 ml, at the age from 6 months to 1 year - 2.5-4 ml. For diseases caused by Streptococcus pyogenes, the course of treatment is at least 10 days.

For uncomplicated gonorrhea of ​​the urethra and cervix - 400 mg once.

In case of impaired renal function, the dose is set depending on the CC in the blood serum: with CC 21-60 ml / min or in patients on hemodialysis, the daily dose should be reduced by 25%; with a CC of 20 ml / min or less or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times. Suspension preparation method: turn the bottle over and shake the powder. Add 40 ml of chilled boiled water in 2 stages and shake until a homogeneous suspension is formed. After that, it is necessary to allow the suspension to settle for 5 minutes to ensure complete dissolution of the powder. Shake the prepared suspension well before use.


Contraindications for use

Hypersensitivity to cephalosporins and penicillins.

Application during pregnancy and lactation

Application during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, use during lactation should stop breastfeeding.

Application for impaired renal function

In case of impaired renal function (with CC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%. With CC ≤20 ml / min, the daily dose should be reduced by 2 times.

Use in children

Use with caution in children under 6 months of age.

Use in elderly patients

Use with caution in elderly patients.

Special instructions


Precautions should be used in elderly patients, patients with chronic renal failure or pseudomembranous colitis (in history), in children under 6 months of age.

With prolonged use, it is possible to disrupt the normal intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In patients with a history of allergic reactions to penicillins, hypersensitivity to cephalosporin antibiotics is possible.

During treatment, a positive direct Coombs' reaction and a false positive urine glucose reaction are possible.


Side Effects

Allergic reactions: urticaria, skin flushing, pruritus, itching in the genital area, eosinophilia, fever, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). From the nervous system: headache, dizziness, tinnitus.

From the genitourinary system: vaginitis.

From the urinary system: impaired renal function, interstitial nephritis.

From the digestive system: nausea, vomiting, stomatitis, diarrhea, abdominal pain, constipation, pseudomembranous enterocolitis, dysbiosis, cholestasis; cholestatic jaundice.

From the side of hematopoiesis: pancytopenia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bleeding.

Laboratory indicators: increased activity of "hepatic" transaminases and alkaline phosphatase, hyperbilirubinemia, increased urea nitrogen, hypercreatininemia, increased prothrombin time. Others: candidiasis, development of hypovitaminosis B, shortness of breath.

Overdose. Treatment: gastric lavage. Hemodialysis and peritoneal dialysis are ineffective.