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Bupropion

Bupropion
Bupropion is an antidepressant that works in the brain and helps treat the symptoms of depression.

Brand: Bupropion

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
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Bupropion 150 mg
360 pills - 150 mg
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$319.99 $0.89 $194.93 Add to cart
270 pills - 150 mg
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180 pills - 150 mg
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120 pills - 150 mg
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30 pills - 150 mg $42.91 $1.43 No Add to cart

Product description

Drug Title

Bupropion

Pharmacological action

Bupropion is a selective inhibitor of catecholamine reuptake (noradrenaline and dopamine) with little effect on indoleamine (serotonin) reuptake, it does not inhibit monoamine oxidase.


Although the mechanism of action of bupropion, like other antidepressants, is currently unknown, it is assumed that its antidepressant effect is carried out by influencing the noradrenergic and/or dopaminergic mediator system.


Clinical efficacy


The efficacy and tolerability of bupropion in sustained release tablets have been investigated in 7 double-blind studies; of these 7 studies, 3 were conducted in Europe in the dose range of interest (up to 300 mg/day). The next 4 studies were conducted in the United States with a flexible dose range up to 450 mg/day. Evidence of long-term effect support was provided by the 1-year study of exacerbation prevention with bupropion; 816 patients received bupropion in the single-blind phase of this study, of whom 423 were randomized to a follow-up double-blind phase (bupropion, 210; placebo, 213).


Bupropion was effective in patients with mild to moderate depression, as well as in patients with severe depression. In pooled European comparative studies, similar degrees of superiority of the drug over placebo were noted in both patients with mild to moderate depression (-1.8, p=0.032) and patients with severe depression (-2.3, p=0.041).

Contraindications to use

  • hypersensitivity to bupropion or any other component of the drug;
  • seizure disorders;
  • abrupt withdrawal of alcohol or sedatives (including benzodiazepines);
  • concomitant use of other bupropion-containing drugs (the occurrence of seizures is a dose-dependent effect);
  • history of bulimia or anorexia nervosa (seizures are possible);
  • concomitant use with MAO inhibitors. Bupropion therapy should not be started at least 2 weeks after withdrawal of irreversible MAO inhibitors.
  • Under 18 years of age.

Caution should be exercised in patients with impaired liver function, impaired renal function, cardiovascular disease and decreased seizure threshold.

Use in pregnancy and lactation

The safety of bupropion administration in pregnant women has not been established.


Bupropion may be administered during pregnancy to patients only when the expected benefits of its use outweigh the possible risks.


In a retrospective study (n = 7,005 infants), there was no increase in congenital malformations (2.3%) or cardiovascular malformations (1.1%) associated with maternal bupropion use in the first trimester of pregnancy (n = 1213 infants) compared with use of other antidepressants in the first trimester (n = 4743 infants - 2.3% and 1.1%, respectively); when using bupropion not in the first trimester (n = 1,049 infants; 2.2% and 1.0%, respectively).


Because bupropion and its metabolites penetrate into breast milk, it is recommended that breastfeeding be discontinued during bupropion therapy.

Indications for the drug Bupropion

  • treatment of depression. If adequate response is achieved, continuation of bupropion therapy to prevent exacerbations and relapses of depressive episodes.

Dosing regimen

Bupropion long-acting tablets should be swallowed whole, without chewing, breaking, or crushing, as this may increase the risk of adverse reactions, including seizure disorders.


Treatment of depression


Clinical effects appear 14 days after initiation of therapy. As with all antidepressants, antidepressant effects may set in after several weeks of treatment.


The maximum single dose of slow-release bupropion should not exceed 450 mg. The interval between doses of bupropion should be at least 24 hours after the last dose. The dose should be increased by no more than 100 mg per day for three days.

Adults

Initial treatment


The initial dose of bupropion is 150 mg once daily, in the morning.


If adequate therapeutic response is not achieved, it is recommended that the dose be increased to the usual adult target dose of 300 mg/day once daily.


Increase the dose above 300 mg/day


Increasing the dose to a maximum daily dose of 450 mg once daily is possible for patients who do not show clinical improvement after several weeks of therapy at a dose of 300 mg/day.


Maintenance therapy


Acute episodes of depression require continued treatment for 6 months or more after initial therapeutic response is achieved. The efficacy of bupropion (300 mg/day) has been proven with long-term therapy (up to 1 year).


Children and adolescents


The safety and efficacy of bupropion in patients under 18 years of age have not been established.