|Brand Temovate 15 g|
12 tubes - 15 g
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|$215.99||$18.00||$186.61||Add to cart|
6 tubes - 15 g
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|$113.65||$18.94||$87.65||Add to cart|
|5 tubes - 15 g||$99.19||$19.84||$68.56||Add to cart|
|4 tubes - 15 g||$89.95||$22.49||$44.25||Add to cart|
|3 tubes - 15 g||$77.91||$25.97||$22.74||Add to cart|
|2 tubes - 15 g||$55.91||$27.96||$11.19||Add to cart|
|1 tubes - 15 g||$33.55||$33.55||No||Add to cart|
Pharmacodynamics of Temovate
Mechanism of action
Glucocorticosteroid for external use. Prevents marginal accumulation of neutrophils, reduces inflammatory exudation and production of lymphokines, inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes, has local anti-inflammatory, antipruritic, anti-allergic and anti-exudative effects.
Topical glucocorticosteroids can be systemically absorbed from intact (healthy) skin. The degree of percutaneous absorption of glucocorticosteroids for external use is determined by a number of factors, including the base of the drug and the integrity of the epidermal barrier. Skin occlusion, inflammation and / or other pathological process can also increase percutaneous absorption.
The average maximum plasma concentration of clobetasol (Cmax) is reached 13 hours after the first application and 8 hours after repeated application of 30 g of clobetasol in the form of a cream for external use to healthy skin 0.5 mg / g, and is 0.63 ng / ml. 10 hours after the application of the second dose (30 g) of clobetasol in the form of a cream, its Cmax slightly exceeds the Cmax of the ointment. In a separate study, 3 hours after a single application of 25 g in the form of Clobetasol, a cream for external use of 0.5 mg / g in patients with psoriasis and eczema, Cmax is 2.3 ng / ml and 4.6 ng / ml respectively.
The use of pharmacodynamic endpoints to assess systemic exposure of glucocorticosteroids for external use is necessary due to the fact that the concentration of clobetasol circulating in the blood was well below the detection limit.
After absorption through the skin, glucocorticosteroids for external use are metabolized by the same pharmacokinetic pathways as glucocorticosteroids for systemic use. They are metabolized primarily in the liver.
Indications for use Temovate
Clobetasol is a very high activity corticosteroid for external use, which is indicated for use in adults, the elderly and children over 1 year old for the short-term treatment of persistent symptoms of inflammation and pruritus in dermatoses sensitive to glucocorticosteroid therapy, in case of ineffectiveness of treatment less active glucocorticosteroids.
• Psoriasis (excluding common plaque psoriasis);
• eczema (various forms);
• lichen planus;
• discoid lupus erythematosus;
• dermatoses resistant to therapy with less active glucocorticosteroids for external use.
Temovate method of administration and doses
Outwardly. The cream and ointment are applied in a thin layer to the affected skin 1–2 times a day until improvement occurs. Treatment should not be carried out for more than 4 weeks without evaluating the need for its continuation. With exacerbations of skin diseases, repeated short courses of treatment with Dermovatepossible® are. If it is necessary to continue glucocorticoid therapy, less active drugs should be used. In a particularly resistant cases, especially when hyperkeratosis, anti-inflammatory creams and ointments effect Dermoveyt® can be enhanced by applying to the affected area at night occlusive dressings using PE film. After this, the achieved improvement is supported by the use of the drug without an occlusive dressing.
Before taking this drug, tell your doctor about any medications you are using, food supplements (such as vitamins, natural supplements, etc.), allergic reactions, existing medical conditions, and current health conditions (such as pregnancy, impending surgery, etc.). The side effects of the drug may be more pronounced depending on the condition of your body. Take this medicine as directed by your doctor or follow the directions for use that came with the medicine. The dosage of the drug depends on your condition. Tell your doctor if your condition has not changed or worsened. Important points to discuss with your healthcare provider are listed below.
- Pregnant Planning to become pregnant or breastfeeding
- Avoid contact with eyes
- womenMay interefere with doping tests and sports performance testing
- Do not use this medication for diaper rash
- Professional athletes should consult a specialist before use
If you are taking other drugs or supplements concurrently with this drug, the effectiveness Temovate Cream may change. Tell your healthcare provider about all drugs, vitamins, and supplements you use. Your doctor will be able to make the right dosing plan to avoid negative interactions. Temovate Cream may interact with the following drugs and products:
Hypersensitivity to Temovate Cream is a contraindication. In addition, Temovate Cream should not be used if you have the following conditions:
Temovate Cream overdose
Do not exceed the recommended dose. Overuse of the drug will not relieve your condition, and it can also cause poisoning and serious side effects. If you are aware of an overdose of Temovate Cream, contact the emergency services, the nearest hospital or hospital. Be sure to bring the package, container, or name of the drug with you to facilitate diagnosis.
Do not pass your medications on to other people, even if they are in the same condition as you, or you think that your conditions have a number of similar symptoms, because it can lead to overdose.
- Please consult your healthcare professional or pharmacist, and read the information on the product packaging.
If you miss another dose of your medication, take it as soon as possible. If your next appointment is approaching, you can skip your previous appointment and continue following your usual medication schedule. Do not take an extra dose to make up for a missed appointment. If you encounter this situation on a regular basis, consider setting up reminders or asking a family member to keep track of the schedule. Be sure to contact your doctor to adjust the schedule to compensate for the missed medication intake (in case you missed a significant number of days).
Storage of Temovate Cream
Store the drugs at room temperature, in a cool place and away from direct sunlight. Do not freeze preparations if such a requirement is expressly absent from the instructions. Keep medicines away from animals and children.
Do not flush drugs into the toilet or drainage systems unless such a requirement is expressly specified in the instructions. Medicines disposed of in this manner can cause significant damage to the environment.for more information on the disposal of PleaseTemovate Cream contact your doctor.
Expired Temovate Cream
Even a single dose of expired Temovate Cream is unlikely to produce an adverse event . Be sure to seek the advice of your healthcare professional if you feel faint or sore. In addition, an expired drug may lose its effectiveness against your disease. To ensure your own safety, it is extremely important to refuse to take medicines that have expired. If you have a medical condition that requires constant medication (heart disease, seizures, life-threatening allergic reactions), you need to establish a reliable channel of communication with your drug supplier to ensure that you have a stock of fresh medicines with a normal shelf life at all times.
Below is a list of possible side effects that may be caused by the elements in Temovate Cream. This list is not final. These side effects have been reported earlier, but are not always recorded when using the drug. Some of these side effects can be extremely rare but have incredibly severe consequences. If you find any side effects, contact your doctor immediately. Especially in the case of observing side effects for a long time.
Nettle I dryness at the site of application
If you encounter side effects not listed above, contact your doctor for advice. In addition, you can report side effects you find to your local Food and Drug Administration.