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Brand Retino-A Cream

Brand Retino-A Cream
Retino-A is a topical treatment for acne, improving or eliminating unevenness, wrinkles, rough skin, blemishes, hyper pigmentation of the skin and photoaging.

Brand: Tretinoin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: September 2023
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Package Price Per pill Save Order
Brand Retino-A Cream 0.05 %
9 tubes - 0.05 %
+ 4 free Viagra 100 mg, 3% discount for future orders
$188.19 $20.91 $46.35 Add to cart
5 tubes - 0.05 %
+ 4 free Viagra 100 mg, 3% discount for future orders
$112.75 $22.55 $17.55 Add to cart
3 tubes - 0.05 % $78.18 $26.06 No Add to cart
Brand Retino-A Cream 0.025 %
9 tubes - 0.025 %
+ 4 free Viagra 100 mg, 3% discount for future orders
$168.95 $18.77 $42.70 Add to cart
5 tubes - 0.025 %
+ 4 free Viagra 100 mg, 3% discount for future orders
$105.99 $21.20 $11.59 Add to cart
3 tubes - 0.025 % $70.55 $23.52 No Add to cart

Product description

Pharmacological action of Retino-A

Buy Retino-a ointment in Canada

Retinoid. Structurally close to vitamin A, it is a natural metabolite of retinol. When taken orally, it suppresses the differentiation and growth of a clone of altered blood cells, including human myeloid leukemia cells. The mechanism of action in acute promyelocytic leukemia is probably due to damage caused by the binding of tretinoin to nuclear receptors of retinoic acid.

When applied externally, it enhances cell proliferation in the papillary layer of the skin, reduces the adhesion of cells involved in the formation of acne vulgaris. When treating open acne, it helps to smooth the skin surface without signs of inflammation. When treating closed acne, it promotes their transition to open acne or papules, which then heal without scarring after removing the keratin plug. Prevents the formation of new acne.

Pharmacokinetics

Tretinoin is a natural metabolite of retinol, which is normally present in plasma. After oral administration, tretinoin is absorbed from the gastrointestinal tract. Plasma concentration returns to the original endogenous level 7-12 hours after taking a single dose of 40 mg.

Plasma protein binding is high. Does not cumulate.

T1/2 is 0.7 hours. After oral administration of radioactively labeled tretinoin, about 60% is excreted in the urine and about 30% in the feces. Metabolites are formed by oxidation and glucuronidation.

With long-term use of tretinoin, a decrease in its concentration in plasma is observed, which may be due to the induction of isoenzymes of the CYP system.

Indications for the active substances of Retino-A

Acne treatment with Retino-A ointment

For oral administration: acute promyelocytic leukemia (for the induction of remission) both in patients who have not previously received therapy, and in relapses or refractoriness to standard therapy (daunomycin or cytarabine).

For external use: acne vulgaris (including with the formation of comedones, papules, pustules), drainage acne. Favre-Rakusho disease (nodular cystic elastosis of the skin with comedones).

Dosage regimen of Retino-A

Retino-A cream packaging

Set individually, depending on the indications and stage of the disease, the scheme of anticancer therapy.

Contraindications

Hypersensitivity, for local use - acute inflammatory (including eczematous) skin lesions (dermatitis, seborrhea, etc.), rosacea, wounds, skin burns, photosensitivity, rectal diseases.

Restrictions on use

Lack of reliable contraception in women of childbearing age, intracranial hypertension (especially in children), hypercholesterolemia, hypertriglyceridemia, leukocytosis (more than 5 109/ l), impaired liver and kidney function, pancreatitis, diabetes mellitus, chronic intoxication (in t alcoholic), age over 50, children's age (when administered orally - up to 1 year and up to 12 years - with local use).

Interaction

Incompatible with tetracyclines (the risk of developing intracranial hypertension increases), oral contraceptives containing progesterone (reduces the effect of contraception), vitamin A (the risk of developing hypervitaminosis A), as well as with photosensitizing drugs (sulfonamides, thiazide diuretics and other phenothiazines). and hygiene products that cause desquamation, dryness and irritation of the skin. Tretinoin increases the systemic effect when minoxidil is used topically. When applied topically, the systemic use of retinoid-containing substances, as well as prolonged exposure to the sun, hot climate, UV radiation, increase the risk of adverse reactions. Ketoconazole and other drugs that affect hepatic cytochrome oxidase increase the concentration of tretinoin in plasma. The therapeutic effect when administered locally is enhanced when used together with benzoyl peroxide and antibiotics (should not be administered simultaneously).

Overdose

Symptoms: "retinoic acid syndrome".

Treatment: conduct a course of treatment with dexamethasone (10 mg every 12 hours for 3 days).

Application during pregnancy and lactation

Contraindicated in pregnancy. Prescribing retinoids to pregnant women leads to abortion and impaired fetal formation (impaired formation and development of structures of the central nervous system, eyes, thymus, muscular system, etc.). During treatment, breastfeeding should be discontinued.

Precautions for the substance Tretinoin

When taken orally, treatment is carried out in a hospital under the close supervision of an oncologist or hematologist. Before starting treatment for leukemia, it is necessary to conduct a cytogenetic study to detect changes in chromosomes (in the absence of translocation of chromosome t (15; 17) and / or the correspondingtranscript, PML / RAR-alpha other drugs are indicated). During treatment, it is necessary to control the level of cholesterol, triglycerides, the number of leukocytes, and liver function. Adequate measures and tools should be provided to diagnose and treat possible complications. After stopping treatment in 2-4 weeks, recurrence of acute leukemia is possible. Women (even with anamnestic indications of infertility) need to use adequate contraceptive measures a month before, during and within a month after the completion of the course. The application begins on the 2-3rd day of the normal menstrual cycle. The absence of pregnancy must be confirmed by laboratory methods 2 weeks before the start of treatment, such studies should be carried out at least 1 time per month. You should refrain from using in pediatric practice, since the safety and effectiveness of its use in children have not been determined. With a significant increase in the number of leukocytes in the blood for the prevention of "retinoic acid syndrome", treatment must be combined with a full-dose course of chemotherapy (it is prescribed on the 5th day of treatment - with a total number of leukocytes 6 · 109/ l, on day 10 - with a total number of leukocytes 10 · 109/ l, on day 15 - with a total number of leukocytes of 15 · 109/ l or more, immediately - if treatment is started against the background of an increased number of leukocytes more than 10 · 109/ l).

When applied externally during treatment, the treated areas of the skin should be protected from exposure to sunlight and artificial UV radiation, wind, cold; suntan patients should start treatment after the sunburn has weakened. In case of contact with mucous membranes, rinse with water.


Side effects of Tretinoin

on the part of the cardiovascular system and blood (blood formation, hemostasis): arrhythmia (23%), arterial hypotension (14%), hypertension (11%), phlebitis (11%), heart failure (6%), in 3% of cases - myocardial infarction, myocarditis, pericarditis, pulmonary hypertension, cardiomyopathy; blood clotting disorder (phlebitis, disseminated intravascular coagulation syndrome, intravenous hemorrhage), peripheral edema, ascites, basophilia, hyperhistaminemia, hypercalcemia.

From the nervous system and sensory organs: dizziness (20%), paresthesia (17%), anxiety (20%), insomnia (14%), depression (14%), intracranial hemorrhage (9%), intracranial hypertension (9%) , more often in children), agitation (9%), hallucinations (6%), headache, weakness, fatigue, confusion, agitation, drowsiness, convulsive syndrome, dementia, hallucinations; 3% - agnosia, aphasia, cerebral edema, coma, dysarthria, encephalopathy, hemiplegia, hyporeflexia, tremor, spinal cord injury and other neurological reactions; impaired vision and hearing.

From the digestive tract: gastrointestinal bleeding (34%), abdominal pain (31%), diarrhea (23%), constipation (17%), dyspepsia (14%), hepatosplenomegaly (9%), hepatitis (3%) ), peptic ulcer (3%), nonspecific liver disorders (3%), bullous stomatitis, lack of appetite, nausea and vomiting, changes in body weight, jaundice, pancreatitis.

From the genitourinary system: impaired renal function (11%), dysuria (9%), acute renal failure (3%), enlargement of the prostate (3%), necrosis of the renal tubules (3%).

On the part of the respiratory system: upper respiratory tract infections (63%), dyspnea (60%), respiratory failure (26%), pleurisy (20%), pneumonia (14%), wheezing (14%), expiratory dyspnea (14 %), lower respiratory tract infections (9%), lung tissue infiltration (6%), pulmonary edema (3%), bronchial asthma (3%), laryngeal edema (3%), nonspecific lung diseases (3%), cough , swelling of the nasal mucosa.

On the part of the skin: alopecia, increased sweating, cellulite, dry skin and mucous membranes, xerophthalmia, cheilitis, dermatitis, facial edema, rash, erythema, itching, intradermal hemorrhage; when applied topically - burning sensation, hyperemia, swelling, blistering, peeling, temporary foci of hyper- or hypopigmentation, photosensitization; extremely rarely - contact allergic, exfoliative, bullous dermatitis.

Others: hypothermia, increased levels of triglycerides, cholesterol, transaminases, general pain syndrome (myalgia, bone pain), acidosis, "retinoic acid syndrome" (fever, dry mucous membranes, nausea / vomiting, rash, mucositis, acute respiratory distress syndrome , shortness of breath, feeling of lack of air, pneumonia, laryngeal edema, pulmonary edema, bronchial asthma, infiltration of lung tissue, hyperleukocytosis, hypotension, pleurisy, renal, hepatic or multiple organ failure (possibly fatal), the development of infections (septicemia), lethargy.