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When it is necessary to relieve muscle tension in skeletal muscles, the doctor often prescribes Baclofen, which is indicated for patients with spinal cord lesions.

Brand: Baclofen

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: May 2024
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Baclofen 25 mg
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Baclofen 10 mg
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Product description

Pharmacotherapeutic group

Buy baclofen in Canada

Other centrally acting muscle relaxants.

Pharmacological properties

Baclofen, a derivative of gamma-aminobutyric acid, is a muscle relaxant that acts at the spinal level. Baclofen inhibits monosynaptic and polysynaptic reflexes.

Baclofen helps to reduce painful flexor muscle spasms and spontaneous muscle contractions, which facilitates movement and rehabilitation of patients.

Baclofen can also reduce pain sensitivity.

Baclofen stimulates the secretion of gastric juice.

Indications for use Baclofen

Muscle stimulation with Baclofen

Increased muscle tone:

  • in multiple sclerosis;

  • in diseases of the spinal cord of infectious, degenerative and traumatic genesis (for example, tumors, syringomyelia, motor neuron diseases, trauma);

  • with a stroke;

  • with infantile cerebral palsy;

  • with meningitis;

  • with craniocerebral trauma;

  • with alcoholism (affective disorders).

Dosage regimen of Baclofen

Appearance of Baclofen tablets

Tablets can be divided, which allows you to individually set the lowest effective dose of the drug, without causing side effects in the patient.

Adults are prescribed the drug in an initial dose of 5 mg 3 times / day; gradually increase the dose every 3 days until the optimal therapeutic effect develops (usually up to 30-75 mg / day). For patients who require the use of the drug in higher doses (usually up to 30-75 mg / day), Baclofen is prescribed in tablets of 25 mg. The maximum daily dose is 100 mg (assigned for a short time in a hospital setting). The duration of the course of therapy depends on the clinical condition of the patient. You should not suddenly stop using Baclofen due to the possible appearance of hallucinations and exacerbation of spastic conditions. The drug is withdrawn gradually (within 1-2 weeks).

In patients over the age of 65, the dose of the drug should be increased with caution due to the increased risk of side effects.

In children under 10 years of age, the daily dose is determined at the rate of 0.75-2 mg / kg; agedover 10 years - a maximum of 2.5 mg / kg / day; those. 2.5 mg 4 times / day. If necessary, the dose is increased with caution every 3 days. The average recommended doses for children from 1 to 2 years old are 10-20 mg / day, for children from 2 to 6 years old - 20-30 mg / day, for children from 6 to 10 years old - 30-60 mg / day.

In patients with severe impaired renal function, as well as in patients on hemodialysis, the recommended dose should be reduced to 5 mg / day.

The drug is taken with meals. If you skip the next appointment, you should not take a double dose of the drug.

Contraindications to the use of

  • gastric ulcer and duodenal ulcer;

  • psychosis;

  • Parkinson's disease;

  • epilepsy;

  • seizures (history);

  • chronic renal failure;

  • pregnancy;

  • lactation period (breastfeeding);

  • hypersensitivity to the drug.

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

In experimental studies in rats that were injected with Baclofen at a dose approximately 13 times the recommended maximum dose for humans, umbilical hernia in the fetus was more often observed. There was no teratogenic effect in mice and rabbits, but a decrease in fetal weight and a violation of the process of ossification of the skeleton of the mouse fetus was described when Baclofen was administered in daily doses that were 17 or 34 times higher than the doses used in humans.

In other trials conducted on rats (females) who received Baclofen for 2 years, dose-dependent changes in the ovaries were noted.

Application for violations of liver function

The drug should be prescribed with caution to patients with impaired liver function.

Application for impaired renal function

The use of the drug is contraindicated in chronic renal failure.

Special instructions

During treatment with the drug, the manifestations of psychopathic syndromes, schizophrenia, convulsive states are aggravated, the development of confusion is possible. In these patients, Baclofen should be used with caution and the patient should be under medical supervision.

After a sudden withdrawal of the drug, a state of fear, confusion, hallucinations, psychopathic, manic, paranoid and convulsive states may occur, and spastic conditions may also worsen, so the dose of the drug should be reduced gradually over 1-2 weeks.

Baclofen is excreted in the urine, mostly unchanged, so the drug should be used with caution in patients with renal insufficiency. In these patients, the dose of the drug should be reduced accordingly.

Special care should be taken during treatment with Baclofen in elderly patients (increased risk of undesirable effects).

Caution should be exercised during the use of Baclofen in patients in whom the maintenance of an upright body position and balance or an increase in motor activity depends on an increase in muscle tone.

Baclofen should be used with extreme caution in patients taking antihypertensive drugs (possible drug interactions).

The drug should be used with caution in patients with stroke, respiratory distress, and liver dysfunction.

The drug should be used with caution in patients with increased tone of the bladder sphincter (urinary retention may occur).

In some patients, while using Baclofen, an increase in the activity of AST, alkaline phosphatase and serum glucose levels was observed. Control of laboratory data is shown, especially in patients with hepatic insufficiency and diabetes mellitus.

Influence on the ability to drive vehicles and control mechanisms

Patients taking Baclofen should refrain from potentially hazardous activities associated with the need for increased attention and rapid psychomotor reactions.



  • drowsiness, loss of consciousness, coma, depression of the respiratory center;

  • possible confusion, hallucinations, agitation, impaired accommodation, lack of pupillary reflex, muscle hypotension, clonic convulsions, decreased or absent unconditioned reflexes, decreased peripheral vascular tone, arterial hypotension, bradycardia, decreased body temperature, nausea, vomiting, diarrhea, increased salivation increased activity of LDH, AST and ALP.

Treatment: there is

  • no specific antidote. You should immediately induce vomiting or gastric lavage, and enter activated carbon. Unconscious patients should be intubated prior to gastric lavage. Prescribe an abundant drink, diuretics, with respiratory depression - mechanical ventilation. According to some reports, in case of mild poisoning, physiostigmine administered intravenously (at a dose of 1-2 mg for 5-10 minutes) eliminates side effects from the central nervous system (especially drowsiness and depression of the respiratory center). If there is no reaction after the first dose, the next dose of the drug can be administered in 30-60 minutes. If convulsions occur, diazepam IV should be used with caution.

Drug interactions

With the simultaneous use of baclofen enhances the sedative effect of other drugs that depress the central nervous system, or ethanol.

With simultaneous use with lithium preparations, baclofen can increase motor excitability.

With simultaneous use with tricyclic antidepressants, a significant decrease in muscle tone is possible.

With the simultaneous use of baclofen enhances the effect of antihypertensive drugs (this may lead to the need to change the dosage regimen).

Drugs that can interfere with kidney function (eg, ibuprofen) increase the T1/2 of baclofen, which is the cause of toxic effects.

Patients with Parkinson's disease receiving levodopa preparations with carbidopa, when used simultaneously with baclofen, may experience hallucinations, confusion, and agitation.

Baclofen prolongs fentanyl-induced analgesia.

Side effects

From the side of the central nervous system and the peripheral nervous system:

  • drowsiness, dizziness, gait disturbance, increased fatigue, confusion, apathy, euphoria, depression, paresthesia, ataxia, tremor, nystagmus, accommodation paresis, hallucinations, convulsions, decreased convulsive threshold.

From the digestive system:

  • nausea, vomiting, dry mouth, constipation, diarrhea.

From the urinary system:

  • urinary retention, dysuria, enuresis;

  • with prolonged use - impaired renal function.

From the side of the cardiovascular system:

  • decreased blood pressure, shortness of breath, palpitations, chest pain and loss of consciousness.


  • myalgia, muscle weakness, visual impairment, taste disorder, skin rashes and itching, swelling of the ankle joints, excessive sweating, weight gain, feeling of swelling of the nasal mucosa. In some patients, an increase in the spastic state was observed (a paradoxical reaction to the drug).

Side effects are most often manifested with a rapid increase in the dose of the drug or the use of Baclofen in high doses, as well as in elderly patients. Side effects are often transient and disappear after dose reduction. Severe unwanted symptoms require discontinuation of the drug.