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Atarax

Atarax
Atarax is intended for adults to relieve anxiety, psychomotor agitation, feelings of internal tension, increased irritability in neurological, mental (generalized anxiety and adjustment disorder) and somatic diseases, as well as in chronic alcoholism, alcohol withdrawal syndrome, accompanied by symptoms of psychomotor agitation;

Brand: Hydroxyzine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: November 2023
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Atarax 25 mg
360 pills - 25 mg
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$155.21 $0.43 $204.67 Add to cart
240 pills - 25 mg
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$111.99 $0.47 $127.93 Add to cart
180 pills - 25 mg $89.51 $0.50 $90.43 Add to cart
120 pills - 25 mg $65.93 $0.55 $54.03 Add to cart
90 pills - 25 mg $51.97 $0.58 $38.00 Add to cart
60 pills - 25 mg $41.95 $0.70 $18.03 Add to cart
30 pills - 25 mg $29.99 $1.00 No Add to cart
Atarax 10 mg
360 pills - 10 mg
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$131.91 $0.37 $131.97 Add to cart
180 pills - 10 mg $73.95 $0.41 $57.99 Add to cart
120 pills - 10 mg $55.91 $0.47 $32.05 Add to cart
90 pills - 10 mg $45.95 $0.51 $20.02 Add to cart
60 pills - 10 mg $34.99 $0.58 $8.99 Add to cart
30 pills - 10 mg $21.99 $0.73 No Add to cart

Product description

Pharmacodynamics of Atarax

Buy Atarax in Canada

Aderivative of diphenylmethane, has a moderate anxiolytic activity; also has a sedative, antiemetic, antihistamine and m-anticholinergic effect. Blocks the central m-choline and H1-histaminoreceptors and inhibits the activity of certain subcortical zones. Does not cause mental dependence and addiction. The clinical effect occurs within 15-30 minutes after ingestion of the tablets. It has a positive effect on cognitive abilities, improves memory and attention. Relaxes skeletal and smooth muscles, has bronchodilating and analgesic effects, moderate inhibitory effect on gastric secretion. Hydroxyzine significantly reduces itching in patients with urticaria, eczema and dermatitis. With long-term use, there was no withdrawal syndrome or deterioration of cognitive functions. Polysomnography in patients with insomnia and anxiety clearly demonstrates an increase in the duration of sleep, a decrease in the frequency of nocturnal awakenings after a single dose or repeated administration of hydroxyzine at a dose of 50 mg. A decrease in muscle tension in patients with anxiety was noted when taking the drug at a dose of 50 mg 3 times a day.

Pharmacokinetics

Packaging of Atarax tablets

Absorption - high. Time to reach Cmax after oral administration - 2 hours; T1/2 in adults - 14 hours. Metabolites are found in breast milk.

After taking a single dose of 25 mg, the concentration in adults is 30 mg / ml, after taking 50 mg of hydroxyzine - 70 mg / ml. Bioavailability for oral and intramuscular administration is 80%. Hydroxyzine is more concentrated in the skin than in plasma. The distribution coefficient is 7-16 l / kg in adults. Hydroxyzine penetrates the BBB and the placenta, concentrating to a greater extent in fetal than in maternal tissues. Hydroxyzine is metabolized in the liver. Cetirizine - the main metabolite (45%), is a pronounced H1-blocker. The total Cl of hydroxyzine is 13 ml / min / kg. Only 0.8% of hydroxyzine is excreted unchanged through the kidneys.

In children, the total Cl is 4 times shorter than in adults, T1/2 - 11 hours in children aged 14 years and 4 hours at the age of 1 year.

In elderly patients, T1/2 is 29 hours, the distribution coefficient is 22.5 l / kg.

In patients with liver diseases, T1/2 increased up to 37 hours, the concentration of metabolites in the blood serum is higher than in young patients with normal liver function. The antihistamine effect can last up to 96 hours after administration.

Indications of Atarax®

for adults for relief of anxiety, psychomotor agitation, feelings of internal tension, increased irritability in neurological, mental (generalized anxiety and adjustment disorder) and somatic diseases, as well as in chronic alcoholism, alcohol withdrawal syndrome, accompanied by symptoms of psychomotor agitation;

as a sedative for premedication;

symptomatic therapy of itching.

Contraindications

  • Hypersensitivity to any of the components of the drug, cetirizine and other piperazine derivatives, aminophylline or ethylenediamine;
  • porphyria;
  • pregnancy;
  • period of childbirth;
  • period of breastfeeding.
  • hereditary intolerance to galactose, impaired absorption of glucose-galactose (since the tablets include lactose).

With care: myasthenia gravis; hyperplasia of the prostate gland with clinical manifestations, incl. difficulty urinating, constipation; increased intraocular pressure; dementia; tendency to seizures; patients prone to arrhythmias or receiving drugs that can cause arrhythmias; patients who are simultaneously receiving treatment with other drugs that depress the central nervous system, or anticholinergics (the dose should be reduced); patients with severe and moderate severity of renal failure, as well as with hepatic failure (dose reduction is necessary); elderly patients (the dose is reduced in case of reduced glomerular filtration.

Interaction of Atarax

It is necessary to take into account the potentiating effect of hydroxyzine when combined with drugs that depress the central nervous system, such as narcotic analgesics, barbiturates, tranquilizers, hypnotics, alcohol. In this case, their dosages should be selected individually. avoid joint appointment with MAO inhibitors and holinoblokatorami drug inhibits the pressor effect of epinephrine and anticonvulsant activity of phenytoin, as well as inhibit the operation and betahistine preparations -.. blockers, cholinesterase effect of atropine, belladonna alkaloids, digitalis, antihypertensive agents,  antagonistsH2-receptordo not change under It is an inhibitor of P450 2D6 and in high doses can cause interactions with CYP2D6 substrates.Since hydroxyzine is metabolized in the liver, an increase in its concentration in the blood can be expected when nom appointment with drugs - inhibitors of liver enzymes.

 


Interaction

It is necessary to take into account the potentiating effect of hydroxyzine when combined with drugs that depress the central nervous system, such as narcotic analgesics, barbiturates, tranquilizers, hypnotics, alcohol. In this case, their dosages should be selected individually. Avoid co-administration with MAO inhibitors and anticholinergics. The drug interferes with the pressor effect of adrenaline and the anticonvulsant activity of phenytoin, and also interferes with the action of betahistine and cholinesterase blockers. The effect of atropine, belladonna alkaloids, digitalis, antihypertensive drugs, Hantagonists2receptordoes not change under the action of hydroxyzine. It is an inhibitor of P450 2D6 and in high doses can cause interactions with CYP2D6 substrates. Since hydroxyzine is metabolized in the liver, an increase in its concentration in the blood can be expected when administered together with drugs - inhibitors of liver enzymes.

Dosing and Administration

Inside.

For children: for symptomatic treatment of itching. At the age of 12 months to 6 years - from 1 to 2.5 mg / kg / day in several doses, from 6 years and older - from 1 to 2 mg / kg / day in several doses.

For premedication - 1 mg / kg 1 hour before surgery, as well as additionally the night before anesthesia.

Adults: for symptomatic treatment of anxiety - 25-100 mg per day in divided doses during the day or at night. The standard dose is 50 mg daily (12.5 mg in the morning, 12.5 mg in the afternoon, and 25 mg at night).

In severe cases, the dose may be increased to 300 mg per day.

For premedication in surgical practice - 50-200 mg (1.5-2.5 mg / kg IM) is administered 1 hour before surgery.

For symptomatic treatment of pruritus - the initial dose of 25 mg, if necessary, the dose can be increased 4 times (25 mg 4 times a day).

In elderly patients, treatment begins with half the dose. In renal and / or hepatic insufficiency, the dose should be reduced.

A single maximum dose should not exceed 200 mg, the maximum daily dose should not exceed 300 mg.

Overdose

The manifestation of an overdose of the drug can be a pronounced anticholinergic effect, suppression or paradoxical stimulation of the central nervous system.

Symptoms (in case of significant overdose): nausea, vomiting, involuntary physical activity, hallucinations, impaired consciousness, arrhythmia, arterial hypotension.

Treatment: if there is no spontaneous vomiting, it is recommended to immediately flush the stomach and induce vomiting by artificial means. General supportive measures are shown, including control of vital body functions and monitoring of the patient until the symptoms of intoxication disappear and in the next 24 hours. If a vasopressor effect is required, norepinephrine or metaraminol is prescribed. Epinephrine should not be given. Hemodialysis is not effective. There is no specific antidote.

Special instructions

If it is necessary to conduct allergological tests, the drug should be discontinued 5 days before the study.

Since hydroxyzine can affect attention and the speed of psychomotor reactions, patients should be warned about this if it is necessary to drive a car and mechanisms.

Terms of dispensing from pharmacies

By prescription.

Storage conditions for Atarax®

In a dry place, at a temperature not exceeding 25 ° C.

Side effects

Mild and transient, as a rule, disappear after a few days from the start of treatment or after a dose reduction.

Side effects are mainly associated with CNS depression or paradoxical CNS stimulatory effects, anticholinergic activity or hypersensitivity reactions.

Anticholinergic effects: dry mouth, urinary retention, constipation or impaired accommodation are rare and mainly in elderly patients. Drowsiness, general weakness may occur, especially at the beginning of drug treatment. If these effects do not disappear after a few days from the start of therapy, the dose of the drug must be reduced.

There have been reports of other side effects such as headache, dizziness, excessive sweating, arterial hypotension, tachycardia, allergic reactions, nausea, fever, changes in liver function tests, bronchospasm. No clinically significant respiratory depression was observed when the recommended doses were prescribed.

Involuntary physical activity, incl. very rare cases of tremors and seizures, disorientation were observed with significant overdose.