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Amoxil

Amoxil
Amoxicillin is a semi-synthetic aminopenicillin antibiotic with a broad spectrum of action for oral administration. Inhibits the synthesis of the bacterial cell wall. Has a wide range of antimicrobial action.

Brand: Amoxicillin

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: November 2023
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Amoxil 1000 mg
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10 pills - 1000 mg $33.31 $3.33 No Add to cart
Amoxil 650 mg
270 pills - 650 mg
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Amoxil 500 mg
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Amoxil 250 mg
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Product description

Pharmacological action of Amoxicillin 

Buy Amoxil tablets in Canada

Antibiotic of the group of semisynthetic penicillins of a broad spectrum of action. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect. Active against aerobic gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp .; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Microorganisms that produce penicillinase are resistant to amoxicillin.

In combination with metronidazole, it is active against Helicobacter pylori. It is believed that amoxicillin inhibits the development of Helicobacter pylori resistance to metronidazole.

There is cross-resistance between amoxicillin and ampicillin.

The spectrum of antibacterial action expands with the simultaneous use of amoxicillin and a beta-lactamase inhibitor clavulanic acid. This combination increases the activity of amoxicillin against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other gram-negative bacteria remain resistant.

Pharmacokinetics

Amoxil tablets against infection

When taken orally, amoxicillin is rapidly and completely absorbed from the gastrointestinal tract, not destroyed in the acidic environment of the stomach. Cmax amoxycillin plasma levels achieved after 1-2 h. By increasing the dose to 2 times concentration also increased 2-fold. In the presence of food in the stomach, it does not decrease the total absorption. With intravenous, intramuscular and intramuscular administration, similar concentrations of amoxicillin are achieved in the blood.

Plasma protein binding of amoxicillin is about 20%.

It is widely distributed in tissues and body fluids. Reported high concentrations of amoxicillin in the liver.

T1/2 from plasma is 1-1.5 hours. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the concentration of amoxicillin in the urine is more than 300 μg / ml. A certain amount of amoxicillin is determined in the feces.

In newborns and the elderly, T1/2 may be longer.

In renal failure, T1/2 can be 7-20 hours.

In small amounts, amoxicillin penetrates the BBB during inflammation of the pia mater.

Amoxicillin is removed by hemodialysis.

Indications of the active substances of the drug Amoxicillin

For use as monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by sensitive microorganisms, incl. bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal tract infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea.

For use in combination with metronidazole: chronic gastritis in the acute phase, gastric ulcer and duodenal ulcer in the acute phase, associated with Helicobacter pylori.

Dosage regimen of Amoxicillin tablets

The method of administration and dosing regimen of a particular drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. The compliance of the used dosage form of a particular drug with indications for use and dosage regimen should be strictly observed.

Packaging of Amoxil tablets

Individual. For oral administration, a single dose for adults and children over 10 years old (weighing more than 40 kg) is 250-500 mg, with a severe course of the disease - up to 1 g. For children aged 5-10 years, a single dose is 250 mg; at the age of 2 to 5 years - 125 mg. The interval between doses is 8 hours. For children weighing less than 40 kg, the daily dose, depending on the indications and the clinical situation, may be 20-100 mg / kg in 2-3 doses.

In the treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecid). In patients with impaired renal function with CC 10-40 ml / min, the interval between doses should be increased to 12 hours; if CC is less than 10 ml / min, the interval between doses should be 24 hours.

For parenteral administration to adults, intramuscularly - 1 g 2 times / day, intravenously (with normal renal function) - 2-12 g / day. Children in / m - 50 mg / kg / day, single dose - 500 mg, frequency of administration - 2 times / day; i / v - 100-200 mg / kg / day. In patients with impaired renal function, the dose and the interval between injections should be adjusted in accordance with the CC values.


Contraindications to use

Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and / or cephalosporins.

For use in combination with metronidazole:

  • diseases of the nervous system;

  • hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis;

  • hypersensitivity to nitroimidazole derivatives.

For use in combination with clavulanic acid:

  • a history of indications of liver dysfunction and jaundice associated with taking amoxicillin in combination with clavulanic acid.

Application during pregnancy and lactation

Amoxicillin crosses the placental barrier, in small quantities excreted in breast milk.

If it is necessary to use amoxicillin during pregnancy, the expected benefits of therapy for the mother and the potential risk to the fetus should be carefully weighed.

Use amoxicillin with caution during lactation (breastfeeding).

Application for violations of liver function

Amoxicillin in combination with metronidazole should not be used for liver diseases.

Application for impaired renal function

Patients with impaired renal function, the dose and the interval between injections should be adjusted in accordance with the CC values.

Application in children

Application in children is possible according to the dosage regimen.

Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years of age.

Special instructions

Use with caution in patients prone to allergic reactions.

Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years of age; should not be used for liver diseases.

Alcohol is not recommended against the background of combination therapy with metronidazole.

Drug interactions

Amoxicillin may reduce the effectiveness of oral contraceptives.

With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergism is manifested; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin enhances the effect of indirect anticoagulants by suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index.

Amoxicillin reduces the effect of drugs, in the process of metabolism of which PABA is formed.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which may be accompanied by an increase in its concentration in the blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.

With the combined use of amoxicillin and clavulanic acid, the pharmacokinetics of both components does not change.


Side effects

Allergic reactions:

  • urticaria, erythema, Quincke's edema, rhinitis, conjunctivitis;

  • rarely - fever, joint pain, eosinophilia;

  • in isolated cases - anaphylactic shock.

Effects associated with chemotherapeutic action: the

  • development of superinfections is possible (especially in patients with chronic diseases or reduced body resistance).

With prolonged use in high doses:

  • dizziness, ataxia, confusion, depression, peripheral neuropathy, convulsions.

Mainly when used in combination with metronidazole:

  • nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis;

  • rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, hematopoietic disorders.

Mainly when used in combination with clavulanic acid:

  • cholestatic jaundice, hepatitis;

  • rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.