Loading...



Shopping cart processing ...
0
Your cart0
Products 0
Price $0.00
Bestsellers Pill categories
Customer Support 24/7
usa canada USA
uk UK
au AU
Live Chat 24/7
Menu
Customer Support 24/7
USA/Canada Toll Free USA
UK UK
AUS AU
Customer Support 24/7
usacanada USA
uk UK
au AU
We accept
  • Visa
  • MasterCard
  • Amex
  • JCB
Currency
USD
Your cart: $0.00 (0 items)
Checkout

Categories list

Choosing us you get:

  • Reliable supplier
  • Low Internet prices
  • Free bonus pills
  • Discount on all future orders
  • Discreet package
  • SSL secure orders
Worldwide Shipping!

Testimonials:

  • Mike Daniel Hereford, UK
    Thanks today I got my order which I made 9 days ago. Bonus Pills and 10% discount code is attached. Thanks.
More info »

Allegra

Allegra
Allegra - an antihistamine drug, as an active ingredient fexofenadine hydrochloride, widely used as a symptomatic therapy of allergic rhinitis (AR) (120 mg tablets) and idiopathic urticaria (180 mg tablets).

Brand: Fexofenadine

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: September 2023
Package Price Per pill Save Order
Allegra 180 mg
240 pills - 180 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$165.99 $0.69 $105.93 Add to cart
180 pills - 180 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$131.99 $0.73 $71.95 Add to cart
120 pills - 180 mg $91.99 $0.77 $43.97 Add to cart
90 pills - 180 mg $73.99 $0.82 $27.98 Add to cart
60 pills - 180 mg $53.99 $0.90 $13.99 Add to cart
30 pills - 180 mg $33.99 $1.13 No Add to cart
Allegra 120 mg
240 pills - 120 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$161.95 $0.67 $77.97 Add to cart
180 pills - 120 mg
+ 4 free Viagra 100 mg, 3% discount for future orders
$125.99 $0.70 $53.95 Add to cart
120 pills - 120 mg $87.99 $0.73 $31.97 Add to cart
90 pills - 120 mg $69.99 $0.78 $19.98 Add to cart
60 pills - 120 mg $48.99 $0.82 $10.99 Add to cart
30 pills - 120 mg $29.99 $1.00 No Add to cart

Product description

Pharmacodynamics of Allegra tablets

Allegra antihistamine in Canada

Fexofenadine (pharmacologically active metabolite of terfenadine) is an antihistamine with selective antagonistic activity to H1-receptors without anticholinergic and αblocking1-adrenergic receptoraction. In addition, fexofenadine does not exhibit sedation and other effects from the central nervous system.

In human studies evaluating blisters and hyperemia caused by histamine, the antihistamine effect of fexofenadine, taken orally 1 or 2 times a day, manifests itself after 1 hour, reaches a maximum after 6 hours and lasts for 24 hours after its administration. Even after 28 days of taking fexofenadine, no development of tolerance to the drug was detected. With a single dose of fexofenadine inside, a dose-dependent increase in the antihistamine effect is observed with an increase in the dose from 10 to 130 mg. Using the same model of antihistamine action, it was found that a dose of at least 130 mg was required for a constant action for 24 hours. The maximum suppression of blistering and skin flushing is more than 80%.

In patients with seasonal allergic rhinitis, who received up to 240 mg of fexofenadine 2 times a day for 2 weeks, the value of the corrected QTc interval (QT corrected) did not differ from that when taking placebo.

Also, there were no changes in the QTc interval when taking fexofenadine by healthy volunteers 60 mg 2 times a day for 6 months, 400 mg 2 times a day for 6.5 days and 240 mg per day for 1 year compared to the interval QTc when taking placebo.

Even at plasma concentrations 32 times higher than therapeutic concentrations in humans, fexofenadine did not affect the delayed-rectification potassium channels in the human heart.

Pharmacokinetics

Treatment of chronic rhinitis with Allegra

Fexofenadine is rapidly absorbed after oral administration, Tmax is approximately 1-3 hours. The average Cmax when taken 120 mg per day is approximately 289 ng / ml, and when taken 180 mg per day - approximately 494 ng / ml.

Fexofenadine is 60–70% bound to plasma proteins.

Fexofenadine is slightly metabolized in and outside the liver, which is confirmed by the fact that it is the only substance detected in significant quantities in the urine and feces of humans and animals.

With a course of taking the drug, the curve of fexofenadine elimination from plasma decreases biexponentially, and the final T1/2 is 11-15 hours.

Pharmacokinetics with a single and course administration of fexofenadine (up to 120 mg twice a day orally) is linear. A dose of 240 mg 2 times a day gives a slightly larger than a proportional (8.8%) increase in AUC, which indicates that the pharmacokinetics of fexofenadine is almost linear in the dose range from 40 to 240 mg per day.

According to the currently available data, most of the dose taken unchanged is excreted in the bile, and up to 10% of the drug is excreted in the urine.

Indications for Allegra

Buy Allegra tablets in Canada

  • seasonal allergic rhinitis (to reduce symptoms) - 120 mg tablets.
  • chronic idiopathic urticaria (to reduce symptoms) - 180 mg tablets.


Overdose

Symptoms: dizziness, drowsiness, dry mouth. Healthy volunteers received single doses up to 800 mg and course doses up to 690 mg 2 times a day for 1 month or 240 mg 2 times a day for 1 year without any significant adverse effects compared to placebo. The maximum tolerated dose for fexofenadine has not been established.

Treatment: gastric lavage, the appointment of activated carbon, if necessary - symptomatic and supportive therapy. Hemodialysis is ineffective.

Special instructions

It is recommended that the time interval between taking fexofenadine and antacids containing aluminum or magnesium hydroxide is at least 2 hours.

For use in children from 6 to 11 years old, 30 mg tablets are available.

Impact on ability to drive and perform work requiring concentration. When taking the drug, it is possible to perform work that requires a high concentration of attention and speed of psychomotor reactions (except for patients with a non-standard reaction). Therefore, it is recommended to check the individual reaction to taking fexofenadine before engaging in such activities.

Contraindications

  • hypersensitivity to any component of the drug;
  • pregnancy;
  • lactation period;
  • children under 12 years of age.

With caution: in patients with chronic renal and hepatic failure, as well as in elderly patients (lack of clinical experience in this category of patients); in patients with cardiovascular diseases, incl. and a history (antihistamines can cause palpitations and tachycardia, see "Side Effects").

Application during pregnancy and lactation

Pregnancy. There is not enough data on the use of fexofenadine by pregnant women. Limited animal studies have shown no evidence of adverse effects on pregnancy, intrauterine development, labor and postnatal development. Fexofenadine should not be used during pregnancy.

Lactation. There are no data on the content of fexofenadine in breast milk when it is taken by breastfeeding women. However, when taking terfenadine, its penetration into the breast milk of lactating women was observed. Therefore, the use of fexofenadine during breastfeeding is not recommended.


Side effects

In placebo-controlled clinical trials, the most frequently (≥1 - ≤10%) adverse events observed were headache (7.3%), drowsiness (2.3%), dizziness (1.5%) and nausea (1 ,five%). With fexofenadine, the incidence of the above adverse effects was similar to that with placebo.

In placebo-controlled studies with a frequency of less than 1% (the same when taking fexofenadine and placebo) and with post-marketing use of the drug, weakness, insomnia, nervousness were noted; sleep disturbances or unusual dreams (paroniria), such as nightmares; tachycardia, palpitations; diarrhea.

In rare cases (≥0.01 - ≤0.1%), exanthema, urticaria, itching and other hypersensitivity reactions such as Quincke's edema, difficulty breathing, shortness of breath, skin hyperemia, systemic anaphylactic reactions were observed.