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The drug Aldactone belongs to the group of potassium-sparing diuretics, which are used in urology, gynecology, dermatology, endocrinology, and the treatment of diseases of the cardiovascular system.

Brand: Spironolactone

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: June 2024
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Aldactone 100 mg
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30 pills - 100 mg $41.95 $1.40 No Add to cart
Aldactone 25 mg
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Product description

Pharmacological action Aldactone

Buy Aldactone in Canada

Potassium-, magnesium-sparing diuretic. It is a competitive antagonist of aldosterone in its effect on the distal nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent section of the collecting ducts and distal tubules), increases the excretion of Na+, Cl- and water and reduces the excretion of K+ and urea, reduces the titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is variable. The antihypertensive effect does not depend on the level of renin in the blood plasma and does not manifest itself at normal blood pressure.

The diuretic effect appears on days 2-5 of treatment.

Pharmacokinetics of Aldactone

After oral administration, it is absorbed from the gastrointestinal tract, absorption is 90%. It is metabolized in the liver, the main active metabolite is canrenone.

T1/2 is 13-24 hours. It is excreted mainly by the kidneys, some amount is excreted in the bile.

Indications of the active substances of the drug Aldactone

Edema in chronic heart failure, liver cirrhosis (especially with the simultaneous presence of hypokalemia and hyperaldosteronism), in nephrotic syndrome.

Treating heart failure with Aldactone

Edema in the II and III trimesters of pregnancy.

Arterial hypertension, incl. with aldosterone-producing adrenal adenoma (as part of combination therapy).

Primary hyperaldosteronism. Aldosterone-producing adrenal adenoma (long-term maintenance therapy in case of contraindication to surgical treatment or in case of refusal from it). Diagnosis of hyperaldosteronism.

Hypokalemia and its prevention in the treatment of saluretics.

Polycystic ovary syndrome, premenstrual syndrome.

Dosage regimen of Aldactone tablets

Instructions for using Aldactone

Set individually depending on the severity of violations of water and electrolyte metabolism and hormonal status.

In case of edematous syndrome - 100-200 mg / day (less often - 300 mg / day) in 2-3 doses (usually in combination with a "loop" and / or thiazide diuretic) daily for 14-21 days. Dose adjustments should be made taking into account the values ​​of the concentration of potassium in plasma. If necessary, courses are repeated every 10-14 days. With pronounced hyperaldosteronism and a reduced content of potassium in plasma - 300 mg / day in 2-3 doses.


Hypersensitivity, Addison's disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, liver failure, diabetes mellitus (with confirmed or suspected chronic renal failure), diabetic nephropathy, pregnancy (I trimester), metabolic acidosis, menstrual irregularities. C or breast enlargement caution. AV block (the possibility of strengthening due to the development of hyperkalemia), decompensated cirrhosis of the liver, surgical interventions, taking drugs that cause gynecomastia, local and general anesthetics, old age.

Special instructions

If it is necessary to simultaneously prescribe NSAIDs, it is necessary to monitor renal function and blood electrolytes. Avoid foods rich in K + during treatment.


Weakens the action of indirect anticoagulants.

Taking the drug reduces the sensitivity of blood vessels to norepinephrine, increases T1 / 2 of digoxin.

Increases the toxic effects of Li +.

Accelerates the metabolism and excretion of carbenoxolone.

GCS and diuretics (benzothiadiazine derivatives, furosemide, ethacrynic acid) enhance and accelerate, NSAIDs reduce the diuretic and natriuretic effects.

Treatment with the drug reduces the effect of anticoagulants (heparin, coumarin derivatives, indandione), the toxicity of cardiac glycosides.

Strengthening the action of diuretics and antihypertensive drugs.

ACE inhibitors, indomethacin, cyclosporine, other potassium-sparing diuretics, K + preparations and potassium supplements - the risk of hyperkalemia.

Side effect

From the digestive system: nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the gastrointestinal tract, intestinal colic, diarrhea or constipation.

From the side of the central nervous system: dizziness, drowsiness, lethargy, headache, lethargy, ataxia.

From the side of metabolism: increased concentration of urea, hypercreatininemia, hyperuricemia, impaired water-salt metabolism and acid-base balance (metabolic hypochloremic acidosis or alkalosis).

From the hematopoietic system: megaloblastosis, agranulocytosis, thrombocytopenia.

From the endocrine system: with prolonged use - gynecomastia, erectile dysfunction in men; in women - dysmenorrhea, amenorrhea, metrorrhagia in menopause, hirsutism, coarsening of the voice, breast tenderness, breast carcinoma.

Allergic reactions: urticaria, maculopapular and erythematous rash, drug fever, itching.

Others: muscle spasms, decreased potency.