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|Albenza 400 mg|
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Pharmacological action of the drug Albenza
Antihelminthicagent, effective for mono- and polyinvasions. Selectively suppresses the polymerization of beta-tubulin, disrupts the activity of the microtubular system of the cells of the intestinal canal of helminths; inhibits glucose utilization, blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death. It is especially effective against larval forms of cestodes - Echinococcus granulosus and Taenia solium, nematodes - Strongyloides stercolatis.
Absorption - low, unchanged in plasma is not determined, bioavailability - low due to metabolism during the "first pass" through the liver. Eating fatty foods increases absorption and Cmax by 5 times. TCmax of albendazole sulfoxide - 2-5 hours. Communication with plasma proteins - 70%. It is found in significant quantities in bile, liver, CSF, urine; penetrates into the wall and liquid of helminth cysts. It is metabolized in the liver to form the primary metabolite (albendazole sulfoxide), which has anthelmintic activity. Albendazole sulfoxide is metabolized to albendazole sulfone (secondary metabolite) and other oxidized products devoid of pharmacological activity. T1 / 2 of albendazole sulfoxide - 8-12 hours. Excreted mainly by the kidneys and in small quantities - with feces. With liver damage, bioavailability increases, while the Cmax of albendazole sulfoxide increases by 2 times, and T1 / 2 is lengthened. Induces cytochrome CYP1A2 in human liver cells.
Indications for taking Albenza
Neurocysticercosis caused by the larval form of pork tapeworm (Taenia solium).
Echinococcosis of the liver, lungs, peritoneum, caused by the larval form of the canine tapeworm (Echinococcus granulosus).
- Mixed helminthiases.
As an aid in the surgical treatment of echinococcosis cysts.
Hypersensitivity, pregnancy, lactation, children (up to 6 years - safety not determined).
Carefully. Oppression of bone marrow hematopoiesis, hepatic failure, cirrhosis of the liver, cysticercosis with the involvement of the retina.
Inside, after a meal, the tablets are not chewed, washed down with water. The daily dose is 0.4 g (at a time), for children - 6 mg / kg. The use of laxative drugs and a special diet are not required. Children under 2 years of age - cysticercosis of the brain: 15 mg / kg / day for 8 days; repeat if necessary.
Ankylostomiasis, enterobiasis, ascariasis: 0.2 g once, if necessary, repeat after 3 weeks.
Strongyloidosis and cestodosis: 0.2 g 1 time per day for 3 days, if necessary, repeat after 3 weeks.
Children over 2 years of age and adults - cysticercosis of the brain: 0.4 g 2 times a day for 8-30 days.
Ascariasis, trichocephalosis, enterobiasis and ankylostomiasis - 0.4 g once, if necessary, repeat after 3 weeks. Giardiasis: 0.4 g once a day for 3 days. Strongyloidosis and cestodosis: 0.4 g 1 time per day for 3 days, if necessary, repeat after 3 weeks.
Dexamethasone and cimetidine increase the concentration of albendazole in the blood.
It is necessary to discontinue therapy with the development of leukopenia.
In case of neurocysticercosis with eye damage, a study of the retina of the eye is necessary before starting treatment (the risk of aggravating its pathology). Women of reproductive age are tested for the absence of pregnancy before starting treatment. During therapy, reliable contraception is required.
Patients receiving high doses should be closely monitored, with constant monitoring of blood and liver function.
Possible side effects
Like all medicines, Albendazole can cause side effects, but not every patient gets them.
If any of the following adverse reactions develop, you should stop taking Albendazole and immediately consult a doctor, or the nearest hospital and emergency department:
The following side effects are very rare and may affect up to 1 patient in 10,000)
- Skin reactions:
Erythema multiforme, characterized by itchy, reddish-purple spots that are mainly located on the skin of the feet and palms, genitals, mucous membranes of the eyes and cavity mouth. Elements of the rash may rise above the level of the skin.
Erythema multiforme is also characterized by symptoms such as weakness and fever.
- Other symptoms of severe skin reactions
Changes in skin color, blistering and nodules, pustules, flaking, redness, pain, itching, and rash can be common. These phenomena can be accompanied by fever, headache and joint pain.
Look for More Serious Symptoms
Patients undergoing treatment for parasitic infections may be diagnosed with a rare but very serious condition called neurocysticercosis. In this case, the patient may not be aware of his condition.
Neurocysticercosis develops as a result of the ingress of the parasite in the larval stage into the human brain. For this disease, Albendazole is also indicated for use.
Tell your doctor right away if you notice any of the following symptoms:
- Unbearable headache that cannot be tolerated
- Nausea and bouts of vomiting
- Convulsions (seizures)
- Visual impairment
Another rare but serious side effect that Albendazole can cause are:
- Darkening of urine or discoloration of
- stools Yellowing of the skin and whites of the eyes
Tell your doctor immediately if you experience these symptoms.
Other possible side effects:
Very common side effects (in more than 1 in 10 patients)
- Changes in the blood test pattern. If you need to donate blood for analysis, inform your doctor that you are taking Albendazole
Frequent side effects (in more than 1 in 100 patients, but less than 1 in 10)
- Upset stomach, nausea, vomiting, or stomach pain
- Thinning or hair loss. However, after you stop taking Albendazole, your hair is restored.
Uncommon side effects (more than 1 in 1000, but less than 1 in 100)
- Liver disease
- Hematopoietic disorders: leukopenia followed by the development of various infections (symptoms: fever, chills, sore throat or mouth ulcers).
Very rare side effects (less than 1 in 10,000)
- Hematopoietic disorders that can cause symptoms such as fatigue, shortness of breath, hematoma, or heavy bleeding (such as nosebleeds).