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|Alavert 10 mg|
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Therapeutic indications of Alavert
Prevention and treatment of the following diseases and conditions:
- seasonal and year-round allergic rhinitis;
- allergic conjunctivitis;
- allergic skin diseases (including chronic idiopathic urticaria);
- pseudo-allergic reactions;
- allergic reactions to insect bites.
Alavert method of administration and dosage
Inside, with water or milk, it is possible to take it with food. The tablet can be chewed if necessary.
Adults and children over 12 years old - 2 dosing spoons (10 ml) 1 time / day; children from 2 to 12 years old weighing more than 30 kg - 2 dosage spoons (10 ml) 1 time / day; weighing less than 30 kg - 1 dosing spoon (5 ml) 1 time / day.
Adults and children over 12 years old - 10 mg (1 table) 1 time / day; children from 3 to 12 years old weighing more than 30 kg - 10 mg (1 table) 1 time / day; with a body weight of less than 30 kg - 5 mg (1/2 table) 1 time / day.
For patients with impaired liver function, it is necessary to prescribe a reduced daily dose of the drug for adults and children weighing more than 30 kg, the dose is 10 mg (2 dosage spoons of suspension or 1 table) every other day.
For children under 12 years of age, the use of a suspension is recommended.
The duration of treatment depends on the duration of the manifestation of the symptoms of the disease. If the patient's condition does not improve within 3 days after starting treatment, then loratadine is ineffective.
Elderly patients or with renal insufficiency do not need dose adjustment.
Patients with severe renal impairment (Cl creatinine <30 ml / min). In adults and children from 6 years of age, the starting dose should be 10 mg (2 dosage spoons of suspension or 1 table) every other day; in children from 3 years old - 5 mg (1 dosage spoon of suspension or 1/2 table) every other day.
Inside. The effervescent tablet is first dissolved in a glass of water (200 ml). The tablets should not be swallowed, chewed, or sucked in the mouth.
The use of syrup is recommended for young children and adults with difficulty swallowing.
Children over 6 years old (weighing more than 30 kg) and adults - 10 mg (2 scoops - 10 ml) of syrup or 1 effervescent table. Once a day. Children 2–6 years old (weighing less than 30 kg) - 5 mg (1 scoop - 5 ml) of syrup 1 time per day.
In patients with hepatic and / or renal insufficiency (Cl creatinine <30 ml / min), the drug is used every other day. Elderly people do not need to reduce the dose.
Inside. Adults and children over 12 years old - 10 mg (1 tab.) 1 time per day. The daily dose is 10 mg. Children from 2 to 12 years old - 5 mg (1/2 tab.) 1 time per day. The daily dose is 5 mg. Children weighing more than 30 kg - 10 mg 1 time per day. The daily dose is 10 mg.
Loratadine refers to antihistamines of systemic action, blockers of H1-histamine receptors. It has anti-allergic, antipruritic, anti-exudative action. Reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles. Antiallergic effect develops within 30 minutes after taking the drug, reaches a maximum after 8-12 hours and lasts 24 hours.
Does not affect the central nervous system and does not cause addiction.
Loratadine is rapidly and completely absorbed from the gastrointestinal tract. The presence of food slows down absorption. Cmax in serum is reached within 1 hour after ingestion. The connection with plasma proteins is more than 95%. It is metabolized in the liver to form an active metabolite of descarboethoxyloratadine.
Does not penetrate the BBB. T1/2 is about 8 hours, in the elderly and in chronic alcoholism it increases. It is excreted in the bile and kidneys.
In chronic renal failure and hemodialysis, the pharmacokinetics practically does not change.
Hypersensitivity to any component of the tablets or suspension.
lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
children under 2 years of age (for suspension); 3 years (for tablets).
With care: liver failure; severe renal failure (Cl creatinine <30 ml / min).
Symptoms: headache, drowsiness, palpitations, which can last for a long time.
Treatment: when taking an excessive amount of Alavert® it is recommended to wash the stomach and prescribe an adsorbent (activated carbon). There is no specific antidote. Alavert® is not excreted by hemodialysis. To date, it is also not known whether Alavertis eliminated® by peritoneal dialysis. After emergency treatment, it is necessary to conduct medical supervision of the patient.
Simultaneous intake of inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) reduces the effectiveness of loratadine.
Possible interaction of the drug with inhibitors of cytochrome isoenzymes, such as CYP3A4 or CYP2D6 (ketoconazole, quinidine, itraconazole, erythromycin, fluoxetine) Alavertincreases the concentration of drug® in blood plasma, which may lead to increased side-effects.
According to the WHO, adverse reactions are classified according to their frequency of development as follows: very often (≥1 / 10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, <1 / 100), rarely (≥1 / 10000, <1/1000) and very rarely (<1/10000); frequency unknown - from the available data it was not possible to establish the frequency of occurrence.
- From the immune system: very rarely - anaphylactic reactions.
- From the nervous system: often - headache, drowsiness, increased nervous irritability, increased fatigue; infrequently - insomnia; very rarely - dizziness.
- From the CCC: very rarely - tachycardia, heart palpitations, syncope, arrhythmia.
- From the gastrointestinal tract: infrequently - increased appetite; very rarely - nausea, dry mouth, gastritis.
- From the liver and biliary tract: very rarely - liver dysfunction.
- On the part of the skin: very rarely - allergic reactions (rash), alopecia.
In addition to the above reactions, children may develop a sedative effect. Adverse events from the central nervous system (headache, drowsiness, increased fatigue) occurred with approximately the same frequency as with placebo ("dummies").