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Acyclovir Cream 5%

Acyclovir Cream 5%
A drug for the treatment of infections of the skin and mucous membranes caused by the herpes simplex virus type I and II (HSV), chickenpox virus and shingles (varicella zoster - VZV).

Brand: Acyclovir

Availability: In Stock
Average Delivery Time: 9 Days
Exp. Date: November 2023
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Package Price Per pill Save Order
Acyclovir Cream 5% 10 g
3 tubes - 10 g $29.95 $9.98 $2.90 Add to cart
1 tubes - 10 g $10.95 $10.95 No Add to cart
Acyclovir Cream 5% 5 g
5 tubes - 5 g $33.95 $6.79 $5.80 Add to cart
3 tubes - 5 g $20.95 $6.98 $2.90 Add to cart
1 tubes - 5 g $7.95 $7.95 No Add to cart

Product description

Pharmacokinetics Aciclovir Cream 

Buy Aciclovir cream in Canada

Absorption of acyclovir from the small intestine after oral administration is passive and incomplete, resulting in a bioavailability of 15-30% and peak plasma concentrations of 1.5-2.5 hours after the dose. Plasma concentration during steady-state equilibrium is 0.52-0.56 mg / ml after administration of 200 mg every 4 hours, i.e. 0.79-1.22 mg / ml after 400 mg every 4 hours. Increasing the dose decreases the bioavailability of Aciclovir. The presence of food in the digestive system does not affect the absorption of Aciclovir. Aciclovir is metabolized in the liver, and two inactive metabolites are formed. Approximately 14% of an oral dose is excreted unchanged in the urine. The elimination half-life (t1 / 2) in patients with normal renal function is 2.5 - 3.3 hours.

The amount of Aciclovir that gets after topical application into the basal layer of the epidermis (the site of infection with herpes simplex viruses) is 30-50% of the concentration achievable by ingestion of the drug. With topical application of Aciclovir in the form of a 5% ointment every 4 to 6 hours, there was no systemic absorption of the drug.

Indications for use

Aciclovir film-coated tablets are used:

  • in the treatment of infections of the skin and mucous membranes caused by herpes simplex viruses of types 1 and 2, including primary and recurrent herpes of the external genital organs (herpes genitalis) in immunocompetent and immunocompromised patients;

  • for the prevention of relapse in cases of recurrent genital herpes (herpes genitalis) in immunocompetent patients;

  • for the prevention of infections caused by herpes simplex viruses in immunocompromised patients;

  • in the treatment of infections caused by varicella-zoster

viruses Aciclovir cream is intended for the topical treatment of skin infections caused by herpes simplex viruses, including primary and recurrent herpes of the external genital organs (herpes genitalis) and lips (herpes labialis).

Reception mode Aciclovir Cream

Infections caused by herpes simplex viruses The usual single dose in the treatment of primary infections is 200 mg of Aciclovir 5 times a day, at intervals of approximately 4 hours during the day. Treatment should be 5 days, and in cases of more severe infections it can be extended up to 10 days.

Herpes simplex viruses

In severely immunocompromised patients, doses of 400 mg are used, following the same dosage regimen.

In the prevention of recurrence of genital herpes in immunocompetent patients, doses of 200 mg of Aciclovir are used 4 times a day, at intervals of about 6 hours; alternatively, doses of 400 mg Aciclovir 2 times a day can be used at intervals of 12 hours. Treatment should be periodically stopped at intervals of 6-12 months, due to the assessment of the patient's condition and illness.

In the prevention of herpes simplex infections in immunocompromised patients, Aciclovir is used in doses of 200-400 mg 4 times a day with a time interval of about 6 hours. In severely immunocompromised patients, as well as in patients with reduced intestinal absorption, Aciclovir is used in a dose of 400 mg, following the same dosage regimen.

Infections caused by varicella-zoster viruses The usual dose is 800 mg Aciclovir 5 times a day, with a time interval of about 4 hours, during the day. The treatment should last 7 days.

In severely immunocompromised patients, as well as in those with reduced absorption from the digestive tract, intravenous Aciclovir is recommended.

Children

Treatment of children with Aciclovir Cream

Treatment of herpes simplex infections and prevention of herpes simplex infections in immunocompromised children

Children over 2 years of age are given the same dosage as adults. For children under 2 years of age, apply half the adult dose.

Treatment of chickenpox (varicella))

A dose of 20 mg Aciclovir / kg body weight (not more than 800 mgis applied 4 times a day, i.e.:

  • in children under 2 years of age: 200 mg of Aciclovir 4 times a day

  • in children aged 2-5 years: 400 mg Aciclovir 4 times a day             

  • in children 6 years and older: 800 mg Aciclovir 4 times a day.

The treatment should last 5 days.

Aciclovir cream is applied to the damaged area 5 times a day, approximately at intervals of 4 hours, taking a break for the night. The treatment should last 5 days. If after five days the skin manifestations have not completely disappeared, the treatment can be extended for another 5 days. It is recommended to start treatment at the very first signs of the disease.



CONTRAINDICATIONS 

Aciclovir is contraindicated in persons with hypersensitivity to Aciclovir or to any of the auxiliary components of the drug.

SPECIAL INSTRUCTIONS 

Aciclovir cream is not applied to the mucous membrane of the mouth, eyes or vagina. It is recommended to apply the cream with rubber gloves in order to prevent infection of other skin areas.

To prevent crystallization of the drug in the tubular apparatus, it is recommended to take a large amount of liquid when administered orally. In cases of impaired renal excretory function and elderly persons, the dose is reduced taking into account Cl creatinine.

During treatment with Aciclovir, especially in severely immunocompromised patients, resistive viruses herpes simplex may appear, which must be taken into account in case of unsatisfactory treatment results. The use of Aciclovir cream during pregnancy is justified in the case when the possible benefit to a pregnant woman outweighs the possible risk to the fetus.

In case of an allergic reaction, the application must be discontinued.

DRUG INTERACTION 

Probenecid slows down excretion (blocks tubular secretion). When Aciclovir is applied topically, no interactions with other drugs have been observed.

Side Effects

The drug is usually well tolerated, however, in the area of ​​application of the cream, a transient burning sensation, acute pain, and slight peeling may appear (with prolonged use of the drug). In isolated cases, allergic manifestations in the form of erythema and itching are possible, angioedema is very rarely possible; in these cases, the drug is canceled and, if necessary, appropriate measures are taken (desensitizing therapy, etc.). Contact dermatitis has been reported very rarely after applying the cream. In susceptibility testing, such cases are associated with the components of the cream base, and not with Aciclovir.